Abnormal Cell Surface Antigen Expression in Individuals with Variant CD45 Splicing and Histiocytosis

@article{Boxall2004AbnormalCS,
  title={Abnormal Cell Surface Antigen Expression in Individuals with Variant CD45 Splicing and Histiocytosis},
  author={Sally Boxall and James McCormick and Peter Beverley and Stephan Strobel and Paola de Filippi and Ritu Dawes and Catherine Klersy and Rita Clementi and Emanuella De Juli and Aline Ferster and Diana Wallace and M. Rita Aric{\`o} and Cezare Danesino and Elma Tchilian},
  journal={Pediatric Research},
  year={2004},
  volume={55},
  pages={478-484}
}
Hemophagocytic lymphohistiocytosis (HLH) and Langerhans cell histiocytosis (LCH) are members of a group of rare heterogenous disorders, the histiocytoses, characterized by uncontrolled accumulation of pleomorphic infiltrates of leukocytes. The etiology of these diseases is mainly unknown. CD45 is a hemopoietic cell specific tyrosine phosphatase essential for antigen receptor mediated signaling in lymphocytes and different patterns of CD45 splicing are associated with distinct functions… CONTINUE READING

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