Abnormal Ca(2+) release and catecholamine-induced arrhythmias in mitochondrial cardiomyopathy.

@article{Tavi2005AbnormalCR,
  title={Abnormal Ca(2+) release and catecholamine-induced arrhythmias in mitochondrial cardiomyopathy.},
  author={Pasi Tavi and Anna B Hansson and S Zhang and Nils-G{\"o}ran Larsson and H{\aa}kan Westerblad},
  journal={Human molecular genetics},
  year={2005},
  volume={14 8},
  pages={1069-76}
}
Mitochondrial dysfunction is implicated in numerous cardiac disorders. It has been assumed that the functional defects are directly related to a decreased rate of mitochondrial ATP production, but recent studies have challenged this idea. Here, we used mice with tissue-specific knockout of mitochondrial transcription factor A (Tfam) that leads to progressive cardiomyopathy. The role of changes in the excitation-contraction (E-C) coupling in cardiomyocytes of these mice was studied by measuring… CONTINUE READING

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