Abnormal Brain Connectivity in Children After Early Severe Socioemotional Deprivation: A Diffusion Tensor Imaging Study

  title={Abnormal Brain Connectivity in Children After Early Severe Socioemotional Deprivation: A Diffusion Tensor Imaging Study},
  author={Thomas J. Eluvathingal and Harry T. Chugani and Michael E. Behen and Csaba Juh{\'a}sz and Otto Muzik and Mohsin Maqbool and Diane C. Chugani and Malek I Makki},
  pages={2093 - 2100}
OBJECTIVES. We previously reported that children who were subjected to early socioemotional deprivation in Romanian orphanages showed glucose hypometabolism in limbic and paralimbic structures, including the orbital frontal gyrus, infralimbic prefrontal cortex, hippocampus/amygdala, lateral temporal cortex, and the brainstem. The present study used diffusion tensor imaging tractography to examine the integrity of white matter tracts that connect these brain regions. METHODS. Fractional… 

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