Abnormal Amygdala-Prefrontal Effective Connectivity to Happy Faces Differentiates Bipolar from Major Depression

@article{Almeida2009AbnormalAE,
  title={Abnormal Amygdala-Prefrontal Effective Connectivity to Happy Faces Differentiates Bipolar from Major Depression},
  author={Jorge C. de Almeida and Amelia Versace and Andrea Mechelli and Stefanie Hassel and Mary L. Phillips},
  journal={Biological Psychiatry},
  year={2009},
  volume={66},
  pages={451-459}
}
BACKGROUND Bipolar disorder is frequently misdiagnosed as major depressive disorder, delaying appropriate treatment and worsening outcome for many bipolar individuals. Emotion dysregulation is a core feature of bipolar disorder. Measures of dysfunction in neural systems supporting emotion regulation might therefore help discriminate bipolar from major depressive disorder. METHODS Thirty-one depressed individuals-15 bipolar depressed (BD) and 16 major depressed (MDD), DSM-IV diagnostic… CONTINUE READING

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