Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation.

@article{Scruggs2009AblationOV,
  title={Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation.},
  author={Sarah B. Scruggs and Aaron C. Hinken and Ariyaporn Thawornkaiwong and Jeffrey Robbins and Lori A Walker and Pieter P. de Tombe and David L. Geenen and Peter M. Buttrick and R. John Solaro},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 8},
  pages={5097-106}
}
There is little direct evidence on the role of myosin regulatory light chain phosphorylation in ejecting hearts. In studies reported here we determined the effects of regulatory light chain (RLC) phosphorylation on in situ cardiac systolic mechanics and in vitro myofibrillar mechanics. We compared data obtained from control nontransgenic mice (NTG) with a transgenic mouse model expressing a cardiac specific nonphosphorylatable RLC (TG-RLC(P-). We also determined whether the depression in RLC… CONTINUE READING