Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis.

@article{Satyanarayana2012AblationOT,
  title={Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis.},
  author={Ande Satyanarayana and Kimberly D. Klarmann and Oksana Gavrilova and Jonathan R. Keller},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2012},
  volume={26 1},
  pages={
          309-23
        }
}
Obesity is a major health concern that contributes to the development of diabetes, hyperlipidemia, coronary artery disease, and cancer. Id proteins are helix-loop-helix transcription factors that regulate the proliferation and differentiation of cells from multiple tissues, including adipocytes. We screened mouse tissues for the expression of Id1 and found that Id1 protein is highly expressed in brown adipose tissue (BAT) and white adipose tissue (WAT), suggesting a role for Id1 in adipogenesis… CONTINUE READING
Highly Cited
This paper has 30 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting

GCCGTGTTAAGGAATCTGCTG, TGAACCAAAGTTGACCACCAG, +15 authors GGCAGGCAGACGAATGTTC TTGTCATCTACGGGCACAAAG
2018
View 1 Excerpt
Method Support