Ablation of the single dynamin of T. brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest.

@article{Chanez2006AblationOT,
  title={Ablation of the single dynamin of T. brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest.},
  author={Anne-Laure Chanez and Adrian B Hehl and Markus Engstler and Andr{\'e} Schneider},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 14},
  pages={2968-74}
}
Mitochondrial fission is mediated by dynamin-like proteins (DLPs). Trypanosoma brucei contains a single DLP, which is the only member of the dynamin superfamily. We have previously shown that expression of the human proapoptotic Bax in T. brucei induces extensive mitochondrial fragmentation. Here we report that Baxinduced mitochondrial fission is abolished in cell lines lacking functional DLP suggesting that the protein is also required for mitochondrial division during the cell cycle… CONTINUE READING

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