Ablation of the Locus Coeruleus Increases Oxidative Stress in Tg-2576 Transgenic but Not Wild-Type Mice

@inproceedings{Hurko2010AblationOT,
  title={Ablation of the Locus Coeruleus Increases Oxidative Stress in Tg-2576 Transgenic but Not Wild-Type Mice},
  author={Orest Hurko and Kurt J. Boudonck and Cathleen Gonzales and Zoe A. Hughes and J. Steve Jacobsen and Peter H. Reinhart and Daniel Crowther},
  booktitle={International journal of Alzheimer's disease},
  year={2010}
}
Mice transgenic for production of excessive or mutant forms of beta-amyloid differ from patients with Alzheimer's disease in the degree of inflammation, oxidative damage, and alteration of intermediary metabolism, as well as the paucity or absence of neuronal atrophy and cognitive impairment. Previous observers have suggested that differences in inflammatory response reflect a discrepancy in the state of the locus coeruleus (LC), loss of which is an early change in Alzheimer's disease but which… CONTINUE READING

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