Ablation of the Kell/Xk complex alters erythrocyte divalent cation homeostasis.

  title={Ablation of the Kell/Xk complex alters erythrocyte divalent cation homeostasis.},
  author={A. Joy Rivera and Siok Yuen Kam and Meng Fatt Ho and Jos{\'e} Rafael Romero and Soohee Lee},
  journal={Blood cells, molecules & diseases},
  volume={50 2},
XK is a putative transporter of unknown function that is ubiquitously expressed and linked through disulfide bonds to Kell protein, an endothelin-3 (ET-3)-converting enzyme. We generated three knockout (KO) mice that lacked either Xk, Kell or both proteins and characterized erythrocyte cation levels, transport and hematological parameters. Absence of Xk or Kell was accompanied by changes in erythrocyte K(+), Mg(2+), Na(+) and Ca(2+) transport that were associated with changes in mean cellular… CONTINUE READING

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