Ablation of the CD9 receptor in human lung cancer cells using CRISPR/Cas alters migration to chemoattractants including IL‐16

  title={Ablation of the CD9 receptor in human lung cancer cells using CRISPR/Cas alters migration to chemoattractants including IL‐16},
  author={D. Blake and Jonathon D Martiszus and Tia H Lone and S. Fenster},
Graphical abstract Figure. No caption available. HighlightsCD9 expression was ablated in A549 cells using CRISPR/Cas technology.Wild‐type A549 cells migrated towards chemoattractants, however, CD9 expression was required in this process.CD9 knockdown cells had a significantly reduced migration towards growth serum and IL‐16.IL‐16 stimulation does not lead to the activation of a stress response in A549 cells. Abstract CD9, a member of the tetraspanin superfamily, has been implicated in… Expand
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