Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting.

@article{Ray2009AblationOL,
  title={Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting.},
  author={Andrew P Ray and Seetha Chebolu and Juan A. Bullones Ram{\'i}rez and Nissar A. Darmani},
  journal={Behavioral neuroscience},
  year={2009},
  volume={123 3},
  pages={701-6}
}
The neurocircuitry mediating the emetic reflex is still incompletely understood, and a key question is the degree to which central and/or peripheral components contribute to the overall vomiting mechanism. Having previously found a significant peripheral component in neurokinin NK-receptor mediated emesis, the authors undertook this study to examine the putative central component. Adult least shrews were injected intracerebroventricularly (icv) with saline or the blood-brain barrier impermeable… CONTINUE READING