Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus.

@article{Saxe2006AblationOH,
  title={Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus.},
  author={Michael D Saxe and Fortunato Battaglia and J Wang and Gael Malleret and Denis J David and James E Monckton and A. Denise Garcia and Michael V Sofroniew and Eric R Kandel and Luca Santarelli and Ren{\'e} Hen and Michael R Drew},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 46},
  pages={17501-6}
}
Although hippocampal neurogenesis has been described in many adult mammals, the functional impact of this process on physiology and behavior remains unclear. In the present study, we used two independent methods to ablate hippocampal neurogenesis and found that each procedure caused a limited behavioral deficit and a loss of synaptic plasticity within the dentate gyrus. Specifically, focal X irradiation of the hippocampus or genetic ablation of glial fibrillary acidic protein-positive neural… CONTINUE READING
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