Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis.

@article{Liu2012AblationOG,
  title={Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis.},
  author={Tong-Fei Liu and Jing-Jie Tang and Pei-Shan Li and Yang Shen and Jia-gui Li and Hong-Hua Miao and Boliang Li and B H Song},
  journal={Cell metabolism},
  year={2012},
  volume={16 2},
  pages={213-25}
}
gp78 is a membrane-anchored ubiquitin ligase mediating the degradation of HMG-CoA reductase (HMGCR) and Insig-1. As a rate-limiting enzyme in cholesterol biosynthesis, HMGCR undergoes rapid sterol-promoted degradation. In contrast, destruction of Insig-1 releases its inhibition on SREBP and stimulates the expression of lipogenic genes. Thus, gp78 has opposite effects on lipid biosynthesis. We here generated liver-specific gp78 knockout (L-gp78(-/-)) mice and showed that although the degradation… CONTINUE READING
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