Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice.

@article{Sun2006AblationOG,
  title={Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice.},
  author={Yuxiang Sun and Mark A Asnicar and Pradip Kumar Saha and Lawrence K Chan and R. G. Smith},
  journal={Cell metabolism},
  year={2006},
  volume={3 5},
  pages={379-86}
}
Ghrelin and leptin are suggested to regulate energy homeostasis as mutual antagonists on hypothalamic neurons that regulate feeding behavior. We employed reverse genetics to investigate the interplay between ghrelin and leptin. Leptin-deficient mice (ob/ob) are hyperphagic, obese, and hyperglycemic. Unexpectedly, ablation of ghrelin in ob/ob mice fails to rescue the obese hyperphagic phenotype, indicating that the ob/ob phenotype is not a consequence of ghrelin unopposed by leptin. Remarkably… CONTINUE READING