Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity

@article{Kazak2019AblationOA,
  title={Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity},
  author={Lawrence Kazak and Janane F Rahbani and Bożena Samborska and Gina Z. Lu and Mark P. Jedrychowski and Mathieu Lajoie and Song Zhang and LeeAnn Ramsay and Florence Y. Dou and Danielle E. Tenen and Edward T Chouchani and Petras P. Dzeja and Ian R. Watson and Linus Tsai and Evan D Rosen and Bruce M Spiegelman},
  journal={Nature metabolism},
  year={2019},
  volume={1},
  pages={360 - 370}
}
Depleting creatine levels in thermogenic adipocytes by inhibiting creatine biosynthesis reduces thermogenesis and causes obesity. However, whether creatine import from the circulation affects adipocyte thermogenesis is unknown. Here we show that deletion of the cell-surface creatine transporter (CrT) selectively in fat (AdCrTKO) substantially reduces adipocyte creatine and phosphocreatine levels, and reduces whole-body energy expenditure in mice. AdCrTKO mice are cold intolerant and become more… Expand
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