Ablation of Stat3 by siRNA alters gene expression profiles in JEG-3 cells: a systems biology approach.

@article{Jiang2009AblationOS,
  title={Ablation of Stat3 by siRNA alters gene expression profiles in JEG-3 cells: a systems biology approach.},
  author={Kaiyu Jiang and L C Krous and Nicholas Knowlton and Y Chen and Mark Barton Frank and Craig Cadwell and Michael Centola and James N. Jarvis},
  journal={Placenta},
  year={2009},
  volume={30 9},
  pages={806-15}
}
Control of inflammation at the maternal-fetal interface is a critical element in mammalian pregnancy. Previous work from our laboratory has shown that Stat3 may be a placental mediator involved in maintaining immunologic homeostasis at the maternal-fetal interface. The aim of the current study is to further elucidate the role of Stat3 in response to inflammation. As ablation of Stat3 in mice results in embryonic lethality, we evaluated the role of Stat3 in vitro using an siRNA approach… CONTINUE READING