Ablation of S1P3 receptor protects mouse soleus from age-related drop in muscle mass, force, and regenerative capacity.

@article{Bond2017AblationOS,
  title={Ablation of S1P3 receptor protects mouse soleus from age-related drop in muscle mass, force, and regenerative capacity.},
  author={M. Bond{\'i} and E. Germinario and M. Pirazzini and G. Zanetti and F. Cencetti and C. Donati and L. Gorza and R. Betto and P. Bruni and D. Danieli-Betto},
  journal={American journal of physiology. Cell physiology},
  year={2017},
  volume={313 1},
  pages={
          C54-C67
        }
}
We investigated the effects of S1P3 deficiency on the age-related atrophy, decline in force, and regenerative capacity of soleus muscle from 23-mo-old male (old) mice. Compared with muscle from 5-mo-old (adult) mice, soleus mass and muscle fiber cross-sectional area (CSA) in old wild-type mice were reduced by ~26% and 24%, respectively. By contrast, the mass and fiber CSA of soleus muscle in old S1P3-null mice were comparable to those of adult muscle. Moreover, in soleus muscle of wild-type… Expand

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