Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model.

@article{Li2005AblationOM,
  title={Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model.},
  author={Yan Feng Li and Tetsuo Minamino and Osamu Tsukamoto and Toshiaki Yujiri and Yasunori Shintani and Ken-ichiro Okada and Yoko Nagamachi and M. Fujita and Akio Hirata and Shoji Sanada and Hiroshi Asanuma and Seiji Takashima and Masatsugu Hori and Gary Leon Johnson and Masafumi Kitakaze},
  journal={Circulation},
  year={2005},
  volume={111 13},
  pages={1672-8}
}
BACKGROUND Migration, proliferation, and matrix-degrading protease expression of smooth muscle cells (SMCs) are major features of intimal hyperplasia after vascular injury. Although MEK kinase 1 (MEKK1) has been shown to regulate cell migration and urokinase plasminogen activator (uPA) expression, the precise role of MEKK1 in this process remains unknown. METHODS AND RESULTS We triggered a vascular remodeling model by complete ligation of the right common carotid artery in wild-type (WT) and… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…