Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function.

@article{Jessen2010AblationOL,
  title={Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function.},
  author={Niels Jessen and Ho-Jin Koh and Clifford D. L. Folmes and Cory S. Wagg and Nobuharu Fujii and B L\ofgren and C. Magdalena Wolf and Charles I. Berul and Michael F. Hirshman and Gary D Lopaschuk and Laurie J Goodyear},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1802 7-8},
  pages={593-600}
}
Energy deprivation in the myocardium is associated with impaired heart function and increased morbidity. LKB1 is a kinase that is required for activation of AMP-activated protein kinase (AMPK) as well as 13 AMPK-related protein kinases. AMPK stimulates ATP production during ischemia and prevents post-ischemic dysfunction. We used the Cre-Lox system to generate mice where LKB1 was selectively knocked out in cardiomyocytes and muscle cells (LKB1-KO) to assess the role of LKB1 on cardiac function… CONTINUE READING