Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.

  title={Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.},
  author={Shoichiro Takeishi and Akinobu Matsumoto and Ichiro Onoyama and Kazuhito Naka and Atsushi Hirao and Keiichi I Nakayama},
  journal={Cancer cell},
  volume={23 3},
Imatinib eradicates dividing progenitor cells of chronic myeloid leukemia (CML) but does not effectively target nondividing leukemia-initiating cells (LICs); thus, the disease often relapse after its discontinuation. We now show that Fbxw7 plays a pivotal role in maintenance of quiescence in LICs of CML by reducing the level of c-Myc. Abrogation of quiescence in LICs by Fbxw7 ablation increased their sensitivity to imatinib, and the combination of Fbxw7 ablation with imatinib treatment resulted… CONTINUE READING
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