Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.

@article{Engelhardt1994AblationOE,
  title={Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.},
  author={John F. Engelhardt and Xiaojing Ye and Benjamin J. Doranz and J. M. Wilson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 13},
  pages={6196-200}
}
First-generation recombinant adenoviruses that lack E1 sequences have shown tremendous promise in animal and human models of gene therapy. Important limitations of these vectors are that recombinant gene expression is transient and inflammation occurs at the site of gene transfer. Our hypothesis for generating vectors with increased persistence is that present recombinant adenoviruses express viral proteins that stimulate cellular immune responses leading to destruction of the infected cells… CONTINUE READING

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