Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development

@inproceedings{Ftterer2012AblationOD,
  title={Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development},
  author={Agnes F{\"u}tterer and {\'A}ngel Raya and Mary Llorente and J. C. Izpis{\'u}a-Belmonte and J. L. de la Pompa and Peter Dr. Klatt and Carlos Mart{\'i}nez-A},
  booktitle={Cell Death and Differentiation},
  year={2012}
}
The death inducer obliterator (Dido) locus encodes three protein isoforms, of which Dido3 is the largest and most broadly expressed. Dido3 is a nuclear protein that forms part of the spindle assembly checkpoint (SAC) and is necessary for correct chromosome segregation in somatic and germ cells. Here we report that specific ablation of Dido3 function in mice causes lethal developmental defects at the onset of gastrulation. Although these defects are associated with centrosome amplification… CONTINUE READING
5
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Molecular structures guide the engineering of chromatin

  • Nucleic acids research
  • 2017
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2010
VIEW 2 EXCERPTS

Mouse ES cell culture system as a model of development.

  • Development, growth & differentiation
  • 2010
VIEW 1 EXCERPT

Cross-talk between BubR1 expression and the commitment to differentiate in adipose-derived mesenchymal stem cells

J Lee, CG Lee, KW Lee, CW. Lee
  • Exp Mol Med
  • 2009
VIEW 1 EXCERPT