Ablation of Cav2.3 / E–type voltage–gated calcium channel results in cardiac arrhythmia and altered autonomic control within the murine cardiovascular system

Abstract

Voltage–gated calcium channels are key components in cardiac electrophysiology. We demonstrate that Cav2.3 is expressed in mouse and human heart and that mice lacking the Cav2.3 voltage–gated calcium channel exhibit severe alterations in cardiac function. Amplified cDNA fragments from murine heart and single cardiomyocytes reveal the expression of three… (More)
DOI: 10.1007/s00395-004-0488-1

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