Ablation of Arg-tRNA-protein transferases results in defective neural tube development


The arginylation branch of the N-end rule pathway is a ubiquitin-mediated proteolytic system in which post-translational conjugation of Arg by ATE1-encoded Arg-tRNA-protein transferase to N-terminal Asp, Glu, or oxidized Cys residues generates essential degradation signals. Here, we characterized the ATE1-/- mice and identified the essential role of N… (More)

4 Figures and Tables


  • Presentations referencing similar topics