Abl tyrosine kinase regulates a Rac/JNK and a Rac/Nox pathway for DNA synthesis and Myc expression induced by growth factors.

@article{Boureux2005AblTK,
  title={Abl tyrosine kinase regulates a Rac/JNK and a Rac/Nox pathway for DNA synthesis and Myc expression induced by growth factors.},
  author={Anthony Boureux and Olivia Furstoss and Val{\'e}rie Simon and Serge Roche},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 16},
  pages={
          3717-26
        }
}
The cytoplasmic tyrosine kinase Abl is a Src substrate required for platelet-derived growth factor (PDGF) receptor signaling leading to Myc expression and DNA synthesis. Abl targets are, however, ill defined. Here we report that the small GTPase Rac is an important effector of its mitogenic function. PDGF-induced Rac activation was impaired in cells with inactive Abl and active Rac overcame the mitogenic defects found in these cells. Rac function required both a Jun N-terminal kinase (JNK) and… CONTINUE READING

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