Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway.

@article{Burton2005AblKR,
  title={Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway.},
  author={Elizabeth A. Burton and Timothy N Oliver and Ann Marie Pendergast},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 20},
  pages={8834-43}
}
Microbial pathogens have evolved diverse strategies to modulate the host cell cytoskeleton to achieve a productive infection and have proven instrumental for unraveling the molecular machinery that regulates actin polymerization. Here we uncover a mechanism for Shigella flexneri-induced actin comet tail elongation that links Abl family kinases to N-WASP-dependent actin polymerization. We show that the Abl kinases are required for Shigella actin comet tail formation, maximal intracellular… CONTINUE READING

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