Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation

  title={Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation},
  author={Patrizia Sini and Angela Cannas and Anthony J Koleske and Pier Paolo Di Fiore and Giorgio Scita},
  journal={Nature Cell Biology},
The non-receptor tyrosine kinase Abl participates in receptor tyrosine kinase (RTK)-induced actin cytoskeleton remodelling, a signalling pathway in which the function of Rac is pivotal. More importantly, the activity of Rac is indispensable for the leukaemogenic ability of the BCR-Abl oncoprotein. Thus, Rac might function downstream of Abl and be activated by it. Here, we elucidate the molecular mechanisms through which Abl signals to Rac in RTK-activated pathways. We show that Sos-1, a dual… CONTINUE READING


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