Abiraterone in metastatic prostate cancer without previous chemotherapy.


BACKGROUND Abiraterone acetate, an androgen biosynthesis inhibitor, improves overall survival in patients with metastatic castration-resistant prostate cancer after chemotherapy. We evaluated this agent in patients who had not received previous chemotherapy. METHODS In this double-blind study, we randomly assigned 1088 patients to receive abiraterone… (More)
DOI: 10.1056/NEJMoa1209096


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