Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity.

@article{Diel2000AbilityOX,
  title={Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity.},
  author={Patrick Diel and Thorsten F. Schulz and Kai Smolnikar and Elisabeth Strunck and Guenter Vollmer and Horst Michna},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2000},
  volume={73 1-2},
  pages={1-10}
}
The function of the uterus is regulated by female sex steroids and it is, therefore, used as the classical target organ to detect estrogenic action. Uterine response to estrogens involves the activation of a large pattern of estrogen-sensitive genes. This fact offers the opportunity to analyze the estrogenic activity of xeno- and phytoestrogens, and the mechanisms of their molecular action by a correlation of the uterotropic activity and their ability to modulate the expression of estrogen… CONTINUE READING
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