Ability of various alkylating agents to induce adaptive and SOS responses: a study with lacZ fusion.

Abstract

We used alkA'-lacZ' and umuC'-lacZ' fused genes and determined the ability of various alkylating agents to induce adaptive and SOS responses. The degree of induction of expression of these genes was quantitatively measured by a simple colorimetric assay of beta-galactosidase activity. SN1 type methylating agents, such as N-methyl-N'-nitro-N-nitrosoguanidine… (More)

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@article{Otsuka1985AbilityOV, title={Ability of various alkylating agents to induce adaptive and SOS responses: a study with lacZ fusion.}, author={M. Otsuka and Yusaku Nakabeppu and Masatomo Sekiguchi}, journal={Mutation research}, year={1985}, volume={146 2}, pages={149-54} }