Ability of sat-1 to transport sulfate, bicarbonate, or oxalate under physiological conditions.

@article{Krick2009AbilityOS,
  title={Ability of sat-1 to transport sulfate, bicarbonate, or oxalate under physiological conditions.},
  author={Wolfgang Krick and Nina Schnedler and Gerhard Burckhardt and Birgitta Christina Burckhardt},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={297 1},
  pages={
          F145-54
        }
}
Tubular reabsorption of sulfate is achieved by the sodium-dependent sulfate transporter, NaSi-1, located at the apical membrane, and the sulfate-anion exchanger, sat-1, located at the basolateral membrane. To delineate the physiological role of rat sat-1, [(35)S]sulfate and [(14)C]oxalate uptake into sat-1-expressing oocytes was determined under various experimental conditions. Influx of [(35)S]sulfate was inhibited by bicarbonate, thiosulfate, sulfite, and oxalate, but not by sulfamate and… 
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The anion exchanger SAT-1 [sulfate anion transporter 1 (Slc26a1)] is considered an important regulator of oxalate and sulfate homeostasis, but the mechanistic basis of these critical roles remain…
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Regulation of the expression of the hepatocellular sulfate-oxalate exchanger SAT-1 (SLC26A1) by glyoxylate: a metabolic link between liver and kidney?
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Sat1 is dispensable for active oxalate secretion in mouse duodenum.
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It is concluded that a DIDS-sensitive basolateral transporter is involved in mediating oxalate secretion across mouse duodenum, but Sat1 itself is dispensable for this process.
Effects of acid-base variables and the role of carbonic anhydrase on oxalate secretion by the mouse intestine in vitro
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Oxalate secretion by the distal colon was dependent on HCO3−, CA and specifically modulated by CO2, whereas the ileum was remarkably unresponsive, providing new insights into the oxalate transport mechanism and how it might be regulated.
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The physiological stimuli proposed to be involved in regulating some of the pathways of transport across the epithelial barrier encompassing intestinal adaptations in response to chronic kidney disease, metabolic acid-base disorders, obesity, and following gastric bypass surgery are examined.
Extracellular Cl− regulates human SO42−/anion exchanger SLC26A1 by altering pH sensitivity of anion transport
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The functional characterization of human SLC26A1 is reported, a 4,4′-diisothiocyanato-2,2′-stilbenedisulfonic acid (DIDS)-sensitive, electroneutral sodium-independent anion exchanger transporting sulfate, oxalate, bicarbonate, thiosulfate, and (with divergent properties) chloride.
The role of intestinal oxalate transport in hyperoxaluria and the formation of kidney stones in animals and man
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This review presents the recent developments and advances in this area over the past 10 years, and put to the test some of the new ideas that have emerged during this time, using human and mouse models.
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