Ability of nitrobenzylthioinosine to cross the blood-brain barrier in rats.

@article{Anderson1996AbilityON,
  title={Ability of nitrobenzylthioinosine to cross the blood-brain barrier in rats.},
  author={Christopher M Anderson and Daniel S. Sitar and Fiona E Parkinson},
  journal={Neuroscience letters},
  year={1996},
  volume={219 3},
  pages={191-4}
}
Nucleoside transport inhibitors that cross the blood-brain barrier may be able to potentiate the neuroprotective effects of adenosine. We tested whether nitrobenzylthioinosine (NBMPR) crosses the blood-brain barrier in three types of experiments. First, intravenous injection of [3H]NBMPR and [14C]sucrose was performed. Brain volume of distribution and brain delivery were greater for [3H]NBMPR than for [14C]sucrose. Second, rats were injected intraperitoneally with NBMPR 5'-monophosphate (NBMPR… CONTINUE READING