Ability of dopamine antagonists to inhibit the locomotor effects of cocaine in sensitized and non-sensitized C57BL/6 mice depends on the challenge dose

@article{Prinssen2003AbilityOD,
  title={Ability of dopamine antagonists to inhibit the locomotor effects of cocaine in sensitized and non-sensitized C57BL/6 mice depends on the challenge dose},
  author={Eric P. M. Prinssen and Francis C. Colpaert and Mark S. Kleven and W. Koek},
  journal={Psychopharmacology},
  year={2003},
  volume={172},
  pages={409-414}
}
  • Eric P. M. Prinssen, Francis C. Colpaert, +1 author W. Koek
  • Published 2003
  • Medicine
  • Psychopharmacology
  • RationaleStudies in rats examining the ability of selective dopamine D2 receptor class antagonists to attenuate the effects of a cocaine challenge have suggested that these agents are less potent in attenuating sensitized as opposed to non-sensitized locomotion. A potential issue with these studies is that the same challenge dose is used in sensitized and control conditions even though that dose may occupy different positions on the respective dose-response curves.ObjectivesTo examine whether… CONTINUE READING
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