Ability of baclofen to prevent somatic manifestations and neurochemical changes during nicotine withdrawal.

Abstract

BACKGROUND Nicotine (NIC), the major active component of tobacco, is critical in the maintenance of the smoking habit. The aims of the present study were to analyze the behavioural and neurochemical variations during NIC withdrawal syndrome in mice, and whether they are prevented with baclofen (BAC, GABA(B) receptor agonist). METHODS Swiss-Webster albino… (More)
DOI: 10.1016/j.drugalcdep.2011.05.017

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