Ability of antigen-specific helper cells to effect a class-restricted increase in total Ig-secreting cells in spleens after immunization with the antigen

@article{Rosenberg1979AbilityOA,
  title={Ability of antigen-specific helper cells to effect a class-restricted increase in total Ig-secreting cells in spleens after immunization with the antigen},
  author={Yvonne J. Rosenberg and Jacques M. Chiller},
  journal={The Journal of Experimental Medicine},
  year={1979},
  volume={150},
  pages={517 - 530}
}
Immunization with antigens stimulates not only B lymphocytes secreting specific antibody but, in addition, results in the generation of very large numbers of splenic Ig-secreting cells which lack specificity for that antigen. The present report examined the nature of the antigens capable of eliciting this effect and the mechanisms whereby B cells could be nonspecifically activated. It is shown that the ability of T-dependent, but not T-independent antigens, to induce such increases requires the… CONTINUE READING

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The relationship of specific antigenic stimulation to serum IgM levels in germfree mice

R. Asofsky, N. S. Ikari, M. B. Hilton
In Advances in Germfree Research and Gonotobiology • 1968
View 5 Excerpts
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Comparison of the developmental kinetics of antibody and immunoglobulin - forming cells in normal and tolerant mice

D. F. Amsbaugh, B. Prescott, P. W. Stashak, R. Asofsky, P. J. Baker
J . Immunol . • 1978

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