Ability of Innate Defence Regulator Peptides IDR-1002, IDR-HH2 and IDR-1018 to Protect against Mycobacterium tuberculosis Infections in Animal Models

@article{RivasSantiago2013AbilityOI,
  title={Ability of Innate Defence Regulator Peptides IDR-1002, IDR-HH2 and IDR-1018 to Protect against Mycobacterium tuberculosis Infections in Animal Models},
  author={B. Rivas-Santiago and J. Casta{\~n}eda-Delgado and Cesar E. Rivas Santiago and Matt Waldbrook and I. Gonzalez-Curiel and J. Le{\'o}n-Contreras and J. Enciso-Moreno and Victor del Villar and J. Mendez-Ramos and R. Hancock and R. Hern{\'a}ndez-Pando},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
  • B. Rivas-Santiago, J. Castañeda-Delgado, +8 authors R. Hernández-Pando
  • Published 2013
  • Biology, Medicine
  • PLoS ONE
  • Tuberculosis is an ongoing threat to global health, especially with the emergence of multi drug-resistant (MDR) and extremely drug-resistant strains that are motivating the search for new treatment strategies. One potential strategy is immunotherapy using Innate Defence Regulator (IDR) peptides that selectively modulate innate immunity, enhancing chemokine induction and cell recruitment while suppressing potentially harmful inflammatory responses. IDR peptides possess only modest antimicrobial… CONTINUE READING
    80 Citations
    Peptide IDR‐1018: modulating the immune system and targeting bacterial biofilms to treat antibiotic‐resistant bacterial infections
    • 106
    • PDF
    Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects.
    • 15
    Perspectives for clinical use of engineered human host defense antimicrobial peptides
    • 49
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 36 REFERENCES
    An anti-infective peptide that selectively modulates the innate immune response
    • 335
    • PDF
    Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
    • 2,823
    • PDF
    The Multiple Faces of Host Defence Peptides and Proteins
    • 5
    Modulating immunity as a therapy for bacterial infections
    • 342
    • PDF