Ability of 5-HT4 receptor ligands to modulate rat striatal dopamine release in vitro and in vivo.

@article{Steward1996AbilityO5,
  title={Ability of 5-HT4 receptor ligands to modulate rat striatal dopamine release in vitro and in vivo.},
  author={Lucinda J. Steward and Jun-lan Ge and Rebecca L. Stowe and Douglas Clifton Brown and Roy Bruton and Peter R. Stokes and Nicholas Barnes},
  journal={British journal of pharmacology},
  year={1996},
  volume={117 1},
  pages={
          55-62
        }
}
1. The ability of 5-HT4 (5-hydroxytryptamine4) receptor ligands to modify dopamine release from rat striatal slices in vitro and in the striatum of freely moving rats was assessed by the microdialysis technique. 2. The release of dopamine from slices of rat striatum continually perfused with Krebs buffer was enhanced by 5-HT4 receptor agonists; 5-HT (10 microM), 5-methoxytryptamine (5-MeOT; 10 microM), renzapride (10 microM) and (S)-zacopride (10 microM) maximally increased dopamine release by… CONTINUE READING
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