Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK toddlers.

@article{Richmond2001AbilityO3,
  title={Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK toddlers.},
  author={Peter C. Richmond and Ray Borrow and David Goldblatt and Jamie Findlow and Sarah Martin and Rhonwen Morris and Keith Cartwright and Elizabeth Miller},
  journal={The Journal of infectious diseases},
  year={2001},
  volume={183 1},
  pages={160-3}
}
To test for immunologic memory after a single dose of meningococcal C conjugate (MCC) vaccine in toddlers, 226 children 12-18 months old were randomized to receive 1 of 3 MCC vaccines, with a C polysaccharide booster 6 months later. The protein conjugate was diphtheria mutant toxoid in 2 vaccines (MCC-CRM(197)) and was tetanus toxoid in the third (MCC-TT). One month after the MCC vaccines, 91%-100% of children had serum bactericidal antibody (SBA) titers > or =8, and 89%-100% had a > or =4-fold… CONTINUE READING