Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis.

@article{Tanos2007Abi1FA,
  title={Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis.},
  author={Barbara E Tanos and Ann Marie Pendergast},
  journal={Cellular signalling},
  year={2007},
  volume={19 7},
  pages={1602-9}
}
The Abl-interactor (Abi) proteins are involved in the regulation of actin polymerization and have recently been shown to modulate epidermal growth factor receptor (EGFR) endocytosis. Here we describe the identification of a novel complex between Abi-1 and the Cbl ubiquitin ligase that is induced by stimulation with EGF. Notably, an Abi-1 mutant lacking the… CONTINUE READING