Abetimus sodium for renal flare in systemic lupus erythematosus: results of a randomized, controlled phase III trial.

@article{Cardiel2008AbetimusSF,
  title={Abetimus sodium for renal flare in systemic lupus erythematosus: results of a randomized, controlled phase III trial.},
  author={Mario Humberto Cardiel and James A. Tumlin and Richard A. Furie and Daniel Wallace and Tenshang Joh and Matthew D. Linnik},
  journal={Arthritis and rheumatism},
  year={2008},
  volume={58 8},
  pages={2470-80}
}
OBJECTIVE To investigate whether treatment with abetimus delays renal flare in patients with lupus nephritis. Secondary objectives included evaluation of the effect of abetimus on C3 levels, anti-double-stranded DNA (anti-dsDNA) antibody levels, use of high-dose corticosteroids and/or cyclophosphamide, and major systemic lupus erythematosus (SLE) flare. METHODS We conducted a randomized, placebo-controlled study of treatment with abetimus at 100 mg/week for up to 22 months in SLE patients… CONTINUE READING

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