Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate.

@article{Isoo2007Abeta42OA,
  title={Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate.},
  author={Noriko Isoo and Chihiro Sato and Hiroyuki Miyashita and Mitsuru Shinohara and Nobumasa Takasugi and Yuichi Morohashi and Shoji Tsuji and Taisuke Tomita and Takeshi Iwatsubo},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 17},
  pages={
          12388-96
        }
}
gamma-Secretase is an atypical aspartyl protease that cleaves amyloid beta-precursor protein to generate Abeta peptides that are causative for Alzheimer disease. gamma-Secretase is a multimeric membrane protein complex composed of presenilin (PS), nicastrin, Aph-1, and Pen-2. Pen-2 directly binds to transmembrane domain 4 of PS and confers proteolytic activity on gamma-secretase, although the mechanism of activation and its role in catalysis remain unknown. Here we show that an addition of… CONTINUE READING

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