Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems.

@article{BaruchSuchodolsky2009Abeta40ES,
  title={Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems.},
  author={Rozena Baruch-Suchodolsky and Bilha Fischer},
  journal={Biochemistry},
  year={2009},
  volume={48 20},
  pages={4354-70}
}
The brains of individuals diagnosed with Alzheimer's disease (AD) are characterized by amyloid plaques, of which the major component is Abeta peptide. Excessive Cu and Fe ions binding to Abeta were suggested to have a deleterious effect on promoting both the aggregation of Abeta and the generation of reactive oxygen species (ROS). Other studies suggested that Abeta plays a protective role by acting as an antioxidant at nanomolar concentrations. The apparent confusion regarding the antioxidant… CONTINUE READING

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