Abeta treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry.

@article{Hoerndli2007AbetaTA,
  title={Abeta treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re-entry.},
  author={Fr{\'e}d{\'e}ric J Hoerndli and Steven Pelech and Andreas Papassotiropoulos and J{\"u}rgen G{\"o}tz},
  journal={The European journal of neuroscience},
  year={2007},
  volume={26 1},
  pages={60-72}
}
Microarrays enable the observation of gene expression in experimental models of Alzheimer's disease (AD), with implications for the human pathology. Histopathologically, AD is characterized by Abeta-containing plaques and tau-containing neurofibrillary tangles. Here, we used a human SH-SY5Y neuroblastoma cell system to assess the role of P301L mutant human tau expression, and treatment with or without Abeta on gene regulation. We found that Abeta and P301L tau expression independently affect… CONTINUE READING

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