Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease.

  title={Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease.},
  author={Nicholas H. Varvel and Kiran Bhaskar and Anita Ramdas Patil and Sanjay W Pimplikar and Karl Herrup and Bruce T Lamb},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={28 43},
Neurons subject to degeneration in Alzheimer's disease (AD) exhibit evidence of re-entry into a mitotic cell cycle even before the development of substantial AD brain pathology. In efforts to identify the initiating factors underlying these cell cycle events (CCEs), we have characterized the appearance of the neuronal CCEs in the genomic-based R1.40 transgenic mouse model of AD. Notably, R1.40 mice exhibit neuronal CCEs in a reproducible temporal and spatial pattern that recapitulates the… CONTINUE READING


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