Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.

@article{Cataldo2004AbetaLI,
  title={Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.},
  author={Anne M. Cataldo and Suzana S. Petanceska and Nicole B Terio and Corrinne M. Peterhoff and Robert Durham and Marc H Mercken and Pankaj D. Mehta and Joseph D. Buxbaum and Vahram Haroutunian and Ralph A. Nixon},
  journal={Neurobiology of aging},
  year={2004},
  volume={25 10},
  pages={1263-72}
}
Early endosomes are a major site of amyloid precursor protein (APP) processing and a convergence point for molecules of pathologic relevance to Alzheimer's disease (AD). Neuronal endosome enlargement, reflecting altered endocytic function, is a disease-specific response that develops years before the earliest stage of AD and Down syndrome (DS). We examined how endocytic dysfunction is related to Abeta accumulation and distribution in early stage AD and DS. We found by ELISA and… CONTINUE READING

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