Abeta ion channels. Prospects for treating Alzheimer's disease with Abeta channel blockers.

Abstract

The main pathological features in the Alzheimer's brain are progressive depositions of amyloid protein plaques among nerve cells, and neurofibrillary tangles within the nerve cells. The major components of plaques are Abeta peptides. Numerous reports have provided evidence that Abeta peptides are cytotoxic and may play a role in the pathogenesis of AD. An… (More)

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@article{Arispe2007AbetaIC, title={Abeta ion channels. Prospects for treating Alzheimer's disease with Abeta channel blockers.}, author={Nelson J. Arispe and Juan C. Diaz and Olga A. Simakova}, journal={Biochimica et biophysica acta}, year={2007}, volume={1768 8}, pages={1952-65} }