Abeta(25-35) and Abeta(1-40) act on different calcium channels in CA1 hippocampal neurons.

@article{Rovira2002Abeta2535AA,
  title={Abeta(25-35) and Abeta(1-40) act on different calcium channels in CA1 hippocampal neurons.},
  author={Catherine Rovira and Nicolas Arbez and Jean Mariani},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={296 5},
  pages={1317-21}
}
The acute effects of beta-amyloid (25-35) and (1-40) on high voltage activated calcium channels were compared in CA1 pyramidal cells of adult mouse hippocampal slices using the whole-cell patch-clamp recording. Bath application of oligomeric beta-amyloid (25-35) reversibly increased the barium current (I(Ba)) to 1.61 (normalized amplitude), while oligomeric beta-amyloid (1-40) reversibly enhanced the I(Ba) to 1.74. Reverse-sequence beta-amyloid [(35-25) and (40-1)] had no effect. The effect of… CONTINUE READING

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