Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.

@article{Bartkova2008AberrationsOT,
  title={Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.},
  author={Jirina Bartkova and Johanna Tommiska and Lenka Oplustilova and Kirsimari Aaltonen and Anitta Tamminen and Tuomas Heikkinen and Martin Mistr{\'i}k and Kristiina Aittom{\"a}ki and Carl Blomqvist and P{\"a}ivi Heikkil{\"a} and Jiri Lukas and Heli Nevanlinna and Jiri Bartek},
  journal={Molecular oncology},
  year={2008},
  volume={2 4},
  pages={296-316}
}
The MRE11, RAD50, and NBS1 genes encode proteins of the MRE11-RAD50-NBS1 (MRN) complex critical for proper maintenance of genomic integrity and tumour suppression; however, the extent and impact of their cancer-predisposing defects, and potential clinical value remain to be determined. Here, we report that among a large series of approximately 1000 breast carcinomas, around 3%, 7% and 10% tumours showed aberrantly reduced protein expression for RAD50, MRE11 and NBS1, respectively. Such defects… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 59 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 82 references

Ten genes for inherited breast cancer.

Cancer cell • 2007
View 4 Excerpts
Highly Influenced

Lack of PTEN sequesters CHK1 and initiates genetic instability.

Cancer cell • 2005
View 5 Excerpts
Highly Influenced

An update on conformation sensitive gel electrophoresis.

Human mutation • 2002
View 4 Excerpts
Highly Influenced

The ATM-mediated DNA-damage response: taking shape.

Trends in biochemical sciences • 2006
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…