Aberrations of TACC1 and TACC3 are associated with ovarian cancer

  title={Aberrations of TACC1 and TACC3 are associated with ovarian cancer},
  author={Brenda Lauffart and Mary M. Vaughan and R. Eddy and David S. Chervinsky and Richard A. Dicioccio and Jennifer D. Black and Ivan H. Still},
  journal={BMC Women's Health},
  pages={8 - 8}
BACKGROUND Dysregulation of the human Transforming Acidic Coiled Coil (TACC) genes is thought to be important in the development and progression of multiple myeloma, breast and gastric cancer. Recent, large-scale genomic analysis and Serial Analysis of Gene Expression data suggest that TACC1 and TACC3 may also be involved in the etiology of ovarian tumors from both familial and sporadic cases. Therefore, the aim of this study was to determine the occurrence of alterations of these TACCs in… CONTINUE READING