Aberrations in the mismatch repair genes and the clinical impact on oesophageal squamous carcinomas from a high incidence area in South Africa.

@article{Naidoo2005AberrationsIT,
  title={Aberrations in the mismatch repair genes and the clinical impact on oesophageal squamous carcinomas from a high incidence area in South Africa.},
  author={Rishendran R Naidoo and Amsha Ramburan and Anunathan Reddi and Runjan Chetty},
  journal={Journal of clinical pathology},
  year={2005},
  volume={58 3},
  pages={281-4}
}
AIMS To investigate the incidence of genetic aberrations in the DNA repair genes in a cohort of oesophageal cancers. METHODS One hundred oesophagectomy samples of squamous cell carcinoma were studied. Normal and tumour DNA were isolated using a standard phenol/chloroform extraction procedure. Six recommended microsatellite loci with high informativity were analysed. The following markers were used: D2S123 (2p), D3S659 (3p), D3S1255 (3p), Bat 25 (4q), Bat 26 (2p), and Bat 40 (1p). The results… CONTINUE READING

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References

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Showing 1-10 of 25 references

Epigenetics in carcinogenesis and cancer prevention.

Annals of the New York Academy of Sciences • 2003

Role of DNA mismatch repair defects in the pathogenesis of human cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2003

Frequent inactivation of the TP53 gene in esophageal squamous cell carcinoma from a high-risk population in China.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2001

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